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<map name="Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins" id="5" nw_id="0" width="950" height="850" create_date="Aug 23, 2007" modified="Nov 23, 2017" publicated="2007-08-24 15:13:54.0 +4:00" description="&lt;html&gt;&#xA;  &lt;head&gt;&#xA;    &#xA;  &lt;/head&gt;&#xA;  &lt;body&gt;&#xA;    &lt;p&gt;&#xA;      &lt;b&gt;Regulation of Apoptosis by Mitochondrial Proteins&lt;/b&gt;&#xA;    &lt;/p&gt;&#xA;    &lt;p&gt;&#xA;      Apoptosis is an evolutionarily conserved type of programmed cell death &#xA;      essential for development, homeostasis, and self-defense against &#xA;      infection. It can be triggered by a number of factors including UV- or &#xA;      gamma-irradiation, chemotherapeutic drugs, or signaling by death &#xA;      receptors. There are two major pathways in mammals that are involved in &#xA;      the initiation of apoptosis. These are the &amp;quot;extrinsic&amp;quot; death receptor &#xA;      pathway, and the &amp;quot;intrinsic&amp;quot; mitochondrial pathway. These pathways can &#xA;      act independently to initiate the death machinery, however there is &#xA;      delicate coordination and cross talk between these pathways that leads &#xA;      to the activation of the caspase cascade [&lt;u&gt;&lt;a href=&quot;#PBM_5_15640619&quot;&gt;1&lt;/a&gt;&lt;/u&gt;], &#xA;      [&lt;u&gt;&lt;a href=&quot;#PBM_5_15706096&quot;&gt;2&lt;/a&gt;&lt;/u&gt;].&#xA;    &lt;/p&gt;&#xA;    &lt;p&gt;&#xA;      Activation of the death domain receptors, such as Tumor necrosis factor &#xA;      receptor superfamily member 1A (&lt;b&gt;TNF-R1&lt;/b&gt;) and Fas TNF receptor &#xA;      superfamily member 6 (&lt;b&gt;FasR(CD95)&lt;/b&gt;) leads to the cleavage and &#xA;      activation of the pro-&lt;b&gt;Caspase-8&lt;/b&gt; [&lt;u&gt;&lt;a href=&quot;#PBM_5_9337844&quot;&gt;3&lt;/a&gt;&lt;/u&gt;], &#xA;      [&lt;u&gt;&lt;a href=&quot;#PBM_5_10235259&quot;&gt;4&lt;/a&gt;&lt;/u&gt;]. &lt;b&gt;Caspase-8&lt;/b&gt; cleaves BH3 &#xA;      interacting domain death agonist (&lt;b&gt;Bid&lt;/b&gt;). Following cleavage, the &#xA;      carboxyl-terminal fragment (&lt;b&gt;tBid&lt;/b&gt;) of &lt;b&gt;Bid&lt;/b&gt; transmits the &#xA;      apoptotic signal from the death receptors to the mitochondria.&lt;b&gt; tBid&lt;/b&gt; &#xA;      targets the mitochondria and induces oligomerization of BCL2-associated &#xA;      X protein (&lt;b&gt;Bax&lt;/b&gt;) and BCL2-antagonist/killer 1 (&lt;b&gt;Bak&lt;/b&gt;) in the &#xA;      cellular outer membrane [&lt;u&gt;&lt;a href=&quot;#PBM_5_11175253&quot;&gt;5&lt;/a&gt;&lt;/u&gt;], [&lt;u&gt;&lt;a href=&quot;#PBM_5_15123718&quot;&gt;6&lt;/a&gt;&lt;/u&gt;]. &#xA;      However, oligomerization of both &lt;b&gt;Bax&lt;/b&gt; and &lt;b&gt;Bak&lt;/b&gt; may occur &#xA;      independently of the cleavage of Bid and/or translocation of Bid from &#xA;      cytosol to mitochondria [&lt;u&gt;&lt;a href=&quot;#PBM_5_11402069&quot;&gt;7&lt;/a&gt;&lt;/u&gt;], [&lt;u&gt;&lt;a href=&quot;#PBM_5_12454021&quot;&gt;8&lt;/a&gt;&lt;/u&gt;]. &#xA;      &lt;b&gt;tBid&lt;/b&gt; also forms oligomers in the mitochondrial membrane [&lt;u&gt;&lt;a href=&quot;#PBM_5_11805084&quot;&gt;9&lt;/a&gt;&lt;/u&gt;]. &#xA;      The Bcl-2 family members may function as pore-forming proteins (Bak-, &#xA;      Bax- and Bid-pores) [&lt;u&gt;&lt;a href=&quot;#PBM_5_11175253&quot;&gt;5&lt;/a&gt;&lt;/u&gt;], [&lt;u&gt;&lt;a href=&quot;#PBM_5_10934477&quot;&gt;10&lt;/a&gt;&lt;/u&gt;].&#xA;    &lt;/p&gt;&#xA;    &lt;p&gt;&#xA;      &lt;b&gt;Cytochrome-c&lt;/b&gt; and the second mitochondria-derived activator of &#xA;      caspases &lt;b&gt;Smac/Diablo&lt;/b&gt; are released into cytosol and pass through &#xA;      the Bak-, Bax- and Bid-pores. This leads to rupture of the outer &#xA;      membrane [&lt;u&gt;&lt;a href=&quot;#PBM_5_11964312&quot;&gt;11&lt;/a&gt;&lt;/u&gt;], [&lt;u&gt;&lt;a href=&quot;#PBM_5_15800609&quot;&gt;12&lt;/a&gt;&lt;/u&gt;]. &#xA;      Once released from mitochondria, &lt;b&gt;Cytochrome-c&lt;/b&gt; binds to and &#xA;      activates Apoptotic peptidase activating factor 1 (&lt;b&gt;Apaf-1&lt;/b&gt;). &#xA;      Activated &lt;b&gt;Apaf-1&lt;/b&gt; then forms complexes with pro-&lt;b&gt;Caspase 9. This&lt;/b&gt; &#xA;      results in the activation of caspase cascade and induction of apoptosis [&lt;u&gt;&lt;a href=&quot;#PBM_5_9390557&quot;&gt;13&lt;/a&gt;&lt;/u&gt;].&#xA;    &lt;/p&gt;&#xA;    &lt;p&gt;&#xA;      Anti-apoptotic proteins B-cell CLL/lymphoma 2 (&lt;b&gt;Bcl-2&lt;/b&gt;), BCL2-like &#xA;      1 (&lt;b&gt;Bcl-XL&lt;/b&gt;), BCL2-like 2 (&lt;b&gt;Bcl-W&lt;/b&gt;), BCL2-like 10 (&lt;b&gt;Bcl-B&lt;/b&gt;), &#xA;      BCL2-related protein A1 (&lt;b&gt;BFL1&lt;/b&gt;), and Myeloid cell leukemia &#xA;      sequence 1 (&lt;b&gt;Mcl-1&lt;/b&gt;) suppress apoptosis induced by either &lt;b&gt;Bax&lt;/b&gt; &#xA;      or &lt;b&gt;Bak&lt;/b&gt;. These anti-apoptotic proteins selectively bind to &lt;b&gt;Bax&lt;/b&gt; &#xA;      and &lt;b&gt;Bak, &lt;/b&gt;block their oligomerization and induce closing pores [&lt;u&gt;&lt;a href=&quot;#PBM_5_10809232&quot;&gt;14&lt;/a&gt;&lt;/u&gt;], &#xA;      [&lt;u&gt;&lt;a href=&quot;#PBM_5_11278245&quot;&gt;15&lt;/a&gt;&lt;/u&gt;], [&lt;u&gt;&lt;a href=&quot;#PBM_5_12135371&quot;&gt;16&lt;/a&gt;&lt;/u&gt;], &#xA;      [&lt;u&gt;&lt;a href=&quot;#PBM_5_12721291&quot;&gt;17&lt;/a&gt;&lt;/u&gt;].&#xA;    &lt;/p&gt;&#xA;    &lt;p&gt;&#xA;      Mitochondrially encoded 16S RNA &lt;b&gt;(Humanin&lt;/b&gt;) is another &#xA;      anti-apoptotic peptide that was identified recently. &lt;b&gt;It&lt;/b&gt; prevents &#xA;      the translocation of &lt;b&gt;Bax&lt;/b&gt; from cytosol to mitochondria, blocks Bax &#xA;      association and suppresses &lt;b&gt;Cytochrome c&lt;/b&gt; release from mitochondria &#xA;      into cytosol [&lt;u&gt;&lt;a href=&quot;#PBM_5_12732850&quot;&gt;18&lt;/a&gt;&lt;/u&gt;].&#xA;    &lt;/p&gt;&#xA;    &lt;p&gt;&#xA;      The BH3-only proteins (&lt;b&gt;Bid&lt;/b&gt;, Harakiri BCL2 interacting protein (&lt;b&gt;HRK&lt;/b&gt;), &#xA;      Phorbol-12-myristate-13-acetate-induced protein 1 (&lt;b&gt;NOXA&lt;/b&gt;), &#xA;      Modulator of apoptosis 1 (&lt;b&gt;MAP1&lt;/b&gt;), BCL2-like 11 (&lt;b&gt;BIM&lt;/b&gt;), Bcl2 &#xA;      modifying factor (&lt;b&gt;BMF&lt;/b&gt;), BCL2-interacting killer (&lt;b&gt;BIK&lt;/b&gt;), &#xA;      BCL2-associated agonist of cell death (&lt;b&gt;BAD&lt;/b&gt;), and&lt;b&gt; &lt;/b&gt;BCL2 &#xA;      binding component 3 (&lt;b&gt;Puma&lt;/b&gt;)) monitor cellular well being. &#xA;      Different damage signals trigger their binding to anti-apoptotic &#xA;      proteins, thereby initiating cell death. Some BH3-only proteins exhibit &#xA;      binding to all the anti-apoptotic proteins, while others exhibit marked &#xA;      selectivity. This selectivity accounts for differences in the &#xA;      proapoptotic activity of the BH3-only proteins and apoptosis relies on &#xA;      selective interactions between particular subsets of these proteins [&lt;u&gt;&lt;a href=&quot;#PBM_5_15694340&quot;&gt;19&lt;/a&gt;&lt;/u&gt;].&#xA;    &lt;/p&gt;&#xA;    &lt;p&gt;&#xA;      Mitochondria can also release factors involved in caspase-independent &#xA;      cell death including Apoptosis-inducing factor, mitochondrion-associated &#xA;      1 (&lt;b&gt;Aif&lt;/b&gt;). This protein translocates to the nucleus and induces DNA &#xA;      fragmentation in a caspase-independent manner [&lt;u&gt;&lt;a href=&quot;#PBM_5_15077142&quot;&gt;20&lt;/a&gt;&lt;/u&gt;].&#xA;    &lt;/p&gt;&#xA;    &lt;p&gt;&#xA;      &#xA;    &lt;/p&gt;&#xA;    &lt;p&gt;&#xA;      &#xA;    &lt;/p&gt;&#xA;    &lt;p&gt;&#xA;      &#xA;    &lt;/p&gt;&#xA;    &lt;h2&gt;&#xA;      &#xA;    &lt;/h2&gt;&#xA;    &lt;h2&gt;&#xA;      &#xA;    &lt;/h2&gt;&#xA;    &lt;h2&gt;&#xA;      &#xA;    &lt;/h2&gt;&#xA;    &lt;h2&gt;&#xA;      &#xA;    &lt;/h2&gt;&#xA;    &lt;h2&gt;&#xA;      &#xA;    &lt;/h2&gt;&#xA;    &lt;h2&gt;&#xA;      &#xA;    &lt;/h2&gt;&#xA;    &lt;h2&gt;&#xA;      &#xA;    &lt;/h2&gt;&#xA;    &lt;h2&gt;&#xA;      &#xA;    &lt;/h2&gt;&#xA;    &lt;h2&gt;&#xA;      &#xA;    &lt;/h2&gt;&#xA;    &lt;h2&gt;&#xA;      &#xA;    &lt;/h2&gt;&#xA;    &lt;h2&gt;&#xA;      &#xA;    &lt;/h2&gt;&#xA;    &lt;h2&gt;&#xA;      &#xA;    &lt;/h2&gt;&#xA;    &lt;h2&gt;&#xA;      &#xA;    &lt;/h2&gt;&#xA; 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   &lt;table&gt;&#xA;      &lt;tr&gt;&#xA;        &lt;td valign=&quot;top&quot;&gt;&#xA;          &lt;a name=&quot;NWO_5_34&quot; target=&quot;_blank&quot; href=&quot;/cgi/entity_page.cgi?term=100&amp;id=34&quot;&gt;ANT&lt;/a&gt;&#xA;        &lt;/td&gt;&#xA;        &lt;td&gt;&#xA;          Adenine nucleotide translocases &lt;i&gt;Protein group &lt;/i&gt;&#xA;        &lt;/td&gt;&#xA;      &lt;/tr&gt;&#xA;      &lt;tr&gt;&#xA;        &lt;td valign=&quot;top&quot;&gt;&#xA;          &lt;a name=&quot;NWO_5_2103&quot; target=&quot;_blank&quot; href=&quot;/cgi/entity_page.cgi?term=100&amp;id=2103&quot;&gt;Aif&lt;/a&gt;&#xA;        &lt;/td&gt;&#xA;        &lt;td&gt;&#xA;          Apoptosis-inducing factor 1, mitochondrial&#xA;        &lt;/td&gt;&#xA;      &lt;/tr&gt;&#xA;      &lt;tr&gt;&#xA;        &lt;td valign=&quot;top&quot;&gt;&#xA;          &lt;a name=&quot;NWO_5_60&quot; target=&quot;_blank&quot; href=&quot;/cgi/entity_page.cgi?term=100&amp;id=60&quot;&gt;Apaf-1&lt;/a&gt;&#xA;        &lt;/td&gt;&#xA;        &lt;td&gt;&#xA;          Apoptotic protease-activating factor 1&#xA;        &lt;/td&gt;&#xA;      &lt;/tr&gt;&#xA;      &lt;tr&gt;&#xA;        &lt;td valign=&quot;top&quot;&gt;&#xA;          &lt;a name=&quot;NWO_5_71&quot; target=&quot;_blank&quot; href=&quot;/cgi/entity_page.cgi?term=100&amp;id=71&quot;&gt;BAD&lt;/a&gt;&#xA;        &lt;/td&gt;&#xA;        &lt;td&gt;&#xA;          Bcl2 antagonist of cell death&#xA;        &lt;/td&gt;&#xA;      &lt;/tr&gt;&#xA;      &lt;tr&gt;&#xA;        &lt;td valign=&quot;top&quot;&gt;&#xA;          &lt;a name=&quot;NWO_5_-1698772377&quot; target=&quot;_blank&quot; href=&quot;/cgi/entity_page.cgi?term=100&amp;id=-1698772377&quot;&gt;BFL1&lt;/a&gt;&#xA;        &lt;/td&gt;&#xA;        &lt;td&gt;&#xA;          Bcl-2-related protein A1&#xA;        &lt;/td&gt;&#xA;      &lt;/tr&gt;&#xA;      &lt;tr&gt;&#xA;        &lt;td valign=&quot;top&quot;&gt;&#xA;          &lt;a name=&quot;NWO_5_4042&quot; target=&quot;_blank&quot; href=&quot;/cgi/entity_page.cgi?term=100&amp;id=4042&quot;&gt;BMF&lt;/a&gt;&#xA;        &lt;/td&gt;&#xA;        &lt;td&gt;&#xA;          Bcl-2-modifying factor&#xA;        &lt;/td&gt;&#xA;      &lt;/tr&gt;&#xA;      &lt;tr&gt;&#xA;        &lt;td valign=&quot;top&quot;&gt;&#xA;          &lt;a name=&quot;NWO_5_84&quot; target=&quot;_blank&quot; href=&quot;/cgi/entity_page.cgi?term=100&amp;id=84&quot;&gt;Bak&lt;/a&gt;&#xA;        &lt;/td&gt;&#xA;        &lt;td&gt;&#xA;          Bcl-2 homologous antagonist/killer&#xA;        &lt;/td&gt;&#xA;      &lt;/tr&gt;&#xA;      &lt;tr&gt;&#xA;        &lt;td valign=&quot;top&quot;&gt;&#xA;          &lt;a name=&quot;NWO_5_85&quot; target=&quot;_blank&quot; href=&quot;/cgi/entity_page.cgi?term=100&amp;id=85&quot;&gt;Bax&lt;/a&gt;&#xA;        &lt;/td&gt;&#xA;        &lt;td&gt;&#xA;          Apoptosis regulator BAX&#xA;        &lt;/td&gt;&#xA;      &lt;/tr&gt;&#xA;      &lt;tr&gt;&#xA;        &lt;td valign=&quot;top&quot;&gt;&#xA;          &lt;a name=&quot;NWO_5_86&quot; target=&quot;_blank&quot; href=&quot;/cgi/entity_page.cgi?term=100&amp;id=86&quot;&gt;Bcl-2&lt;/a&gt;&#xA;        &lt;/td&gt;&#xA;        &lt;td&gt;&#xA;          Apoptosis regulator Bcl-2&#xA;        &lt;/td&gt;&#xA;      &lt;/tr&gt;&#xA;      &lt;tr&gt;&#xA;        &lt;td valign=&quot;top&quot;&gt;&#xA;          &lt;a name=&quot;NWO_5_-1291709962&quot; target=&quot;_blank&quot; href=&quot;/cgi/entity_page.cgi?term=100&amp;id=-1291709962&quot;&gt;Bcl-B&lt;/a&gt;&#xA;        &lt;/td&gt;&#xA;        &lt;td&gt;&#xA;          Bcl-2-like protein 10&#xA;        &lt;/td&gt;&#xA;      &lt;/tr&gt;&#xA;      &lt;tr&gt;&#xA;        &lt;td valign=&quot;top&quot;&gt;&#xA;          &lt;a name=&quot;NWO_5_9109&quot; target=&quot;_blank&quot; href=&quot;/cgi/entity_page.cgi?term=100&amp;id=9109&quot;&gt;Bcl-W&lt;/a&gt;&#xA;        &lt;/td&gt;&#xA;        &lt;td&gt;&#xA;          Bcl-2-like protein 2&#xA;        &lt;/td&gt;&#xA;      &lt;/tr&gt;&#xA;      &lt;tr&gt;&#xA;        &lt;td valign=&quot;top&quot;&gt;&#xA;          &lt;a name=&quot;NWO_5_87&quot; target=&quot;_blank&quot; href=&quot;/cgi/entity_page.cgi?term=100&amp;id=87&quot;&gt;Bcl-XL&lt;/a&gt;&#xA;        &lt;/td&gt;&#xA;        &lt;td&gt;&#xA;          Bcl-2-like protein 1&#xA;        &lt;/td&gt;&#xA;      &lt;/tr&gt;&#xA;      &lt;tr&gt;&#xA;        &lt;td valign=&quot;top&quot;&gt;&#xA;          &lt;a name=&quot;NWO_5_88&quot; target=&quot;_blank&quot; href=&quot;/cgi/entity_page.cgi?term=100&amp;id=88&quot;&gt;Bid&lt;/a&gt;&#xA;        &lt;/td&gt;&#xA;        &lt;td&gt;&#xA;          BH3-interacting domain death agonist&#xA;        &lt;/td&gt;&#xA;      &lt;/tr&gt;&#xA;      &lt;tr&gt;&#xA;        &lt;td valign=&quot;top&quot;&gt;&#xA;          &lt;a name=&quot;NWO_5_-2034743228&quot; target=&quot;_blank&quot; href=&quot;/cgi/entity_page.cgi?term=100&amp;id=-2034743228&quot;&gt;Bid &#xA;          = tBid&lt;/a&gt;&#xA;        &lt;/td&gt;&#xA;        &lt;td&gt;&#xA;          Object &lt;b&gt;Bid = tBid&lt;/b&gt;:&lt;br&gt;&lt;i&gt;Protein&lt;/i&gt;&#xA;        &lt;/td&gt;&#xA;      &lt;/tr&gt;&#xA;      &lt;tr&gt;&#xA;        &lt;td valign=&quot;top&quot;&gt;&#xA;          &lt;a name=&quot;NWO_5_2097&quot; target=&quot;_blank&quot; href=&quot;/cgi/entity_page.cgi?term=100&amp;id=2097&quot;&gt;Bik&lt;/a&gt;&#xA;        &lt;/td&gt;&#xA;        &lt;td&gt;&#xA;          Bcl-2-interacting killer&#xA;        &lt;/td&gt;&#xA;      &lt;/tr&gt;&#xA;      &lt;tr&gt;&#xA;        &lt;td valign=&quot;top&quot;&gt;&#xA;          &lt;a name=&quot;NWO_5_4039&quot; target=&quot;_blank&quot; href=&quot;/cgi/entity_page.cgi?term=100&amp;id=4039&quot;&gt;Bim&lt;/a&gt;&#xA;        &lt;/td&gt;&#xA;        &lt;td&gt;&#xA;          Bcl-2-like protein 11&#xA;        &lt;/td&gt;&#xA;      &lt;/tr&gt;&#xA;      &lt;tr&gt;&#xA;        &lt;td valign=&quot;top&quot;&gt;&#xA;          &lt;a name=&quot;NWO_5_914&quot; target=&quot;_blank&quot; href=&quot;/cgi/entity_page.cgi?term=100&amp;id=914&quot;&gt;Caspase-8&lt;/a&gt;&#xA;        &lt;/td&gt;&#xA;        &lt;td&gt;&#xA;          Caspase-8&#xA;        &lt;/td&gt;&#xA;      &lt;/tr&gt;&#xA;      &lt;tr&gt;&#xA;        &lt;td valign=&quot;top&quot;&gt;&#xA;          &lt;a name=&quot;NWO_5_915&quot; target=&quot;_blank&quot; href=&quot;/cgi/entity_page.cgi?term=100&amp;id=915&quot;&gt;Caspase-9&lt;/a&gt;&#xA;        &lt;/td&gt;&#xA;        &lt;td&gt;&#xA;          Caspase-9&#xA;        &lt;/td&gt;&#xA;      &lt;/tr&gt;&#xA;      &lt;tr&gt;&#xA;        &lt;td valign=&quot;top&quot;&gt;&#xA;          &lt;a name=&quot;NWO_5_934&quot; target=&quot;_blank&quot; href=&quot;/cgi/entity_page.cgi?term=100&amp;id=934&quot;&gt;Cytochrome &#xA;          c&lt;/a&gt;&#xA;        &lt;/td&gt;&#xA;        &lt;td&gt;&#xA;          Cytochrome c&#xA;        &lt;/td&gt;&#xA;      &lt;/tr&gt;&#xA;      &lt;tr&gt;&#xA;        &lt;td valign=&quot;top&quot;&gt;&#xA;          &lt;a name=&quot;NWO_5_268&quot; target=&quot;_blank&quot; href=&quot;/cgi/entity_page.cgi?term=100&amp;id=268&quot;&gt;FasR(CD95)&lt;/a&gt;&#xA;        &lt;/td&gt;&#xA;        &lt;td&gt;&#xA;          Tumor necrosis factor receptor superfamily member 6&#xA;        &lt;/td&gt;&#xA;      &lt;/tr&gt;&#xA;      &lt;tr&gt;&#xA;        &lt;td valign=&quot;top&quot;&gt;&#xA;          &lt;a name=&quot;NWO_5_-1321938583&quot; target=&quot;_blank&quot; href=&quot;/cgi/entity_page.cgi?term=100&amp;id=-1321938583&quot;&gt;HRK&lt;/a&gt;&#xA;        &lt;/td&gt;&#xA;        &lt;td&gt;&#xA;          Activator of apoptosis harakiri&#xA;        &lt;/td&gt;&#xA;      &lt;/tr&gt;&#xA;      &lt;tr&gt;&#xA;        &lt;td valign=&quot;top&quot;&gt;&#xA;          &lt;a name=&quot;NWO_5_-94985659&quot; target=&quot;_blank&quot; href=&quot;/cgi/entity_page.cgi?term=100&amp;id=-94985659&quot;&gt;Humanin&lt;/a&gt;&#xA;        &lt;/td&gt;&#xA;        &lt;td&gt;&#xA;          Putative humanin peptide&#xA;        &lt;/td&gt;&#xA;      &lt;/tr&gt;&#xA;      &lt;tr&gt;&#xA;        &lt;td valign=&quot;top&quot;&gt;&#xA;          &lt;a name=&quot;NWO_5_381&quot; target=&quot;_blank&quot; href=&quot;/cgi/entity_page.cgi?term=100&amp;id=381&quot;&gt;IGF-1 &#xA;          receptor&lt;/a&gt;&#xA;        &lt;/td&gt;&#xA;        &lt;td&gt;&#xA;          Insulin-like growth factor 1 receptor&#xA;        &lt;/td&gt;&#xA;      &lt;/tr&gt;&#xA;      &lt;tr&gt;&#xA;        &lt;td valign=&quot;top&quot;&gt;&#xA;          &lt;a name=&quot;NWO_5_4050&quot; target=&quot;_blank&quot; href=&quot;/cgi/entity_page.cgi?term=100&amp;id=4050&quot;&gt;MAP1&lt;/a&gt;&#xA;        &lt;/td&gt;&#xA;        &lt;td&gt;&#xA;          Modulator of apoptosis 1&#xA;        &lt;/td&gt;&#xA;      &lt;/tr&gt;&#xA;      &lt;tr&gt;&#xA;        &lt;td valign=&quot;top&quot;&gt;&#xA;          &lt;a name=&quot;NWO_5_4088&quot; target=&quot;_blank&quot; href=&quot;/cgi/entity_page.cgi?term=100&amp;id=4088&quot;&gt;Mcl-1&lt;/a&gt;&#xA;        &lt;/td&gt;&#xA;        &lt;td&gt;&#xA;          Induced myeloid leukemia cell differentiation protein Mcl-1&#xA;        &lt;/td&gt;&#xA;      &lt;/tr&gt;&#xA;      &lt;tr&gt;&#xA;        &lt;td valign=&quot;top&quot;&gt;&#xA;          &lt;a name=&quot;NWO_5_4047&quot; target=&quot;_blank&quot; href=&quot;/cgi/entity_page.cgi?term=100&amp;id=4047&quot;&gt;NOXA&lt;/a&gt;&#xA;        &lt;/td&gt;&#xA;        &lt;td&gt;&#xA;          Phorbol-12-myristate-13-acetate-induced protein 1&#xA;        &lt;/td&gt;&#xA;      &lt;/tr&gt;&#xA;      &lt;tr&gt;&#xA;        &lt;td valign=&quot;top&quot;&gt;&#xA;          &lt;a name=&quot;NWO_5_4048&quot; target=&quot;_blank&quot; href=&quot;/cgi/entity_page.cgi?term=100&amp;id=4048&quot;&gt;PUMA&lt;/a&gt;&#xA;        &lt;/td&gt;&#xA;        &lt;td&gt;&#xA;          Bcl-2-binding component 3&#xA;        &lt;/td&gt;&#xA;      &lt;/tr&gt;&#xA;      &lt;tr&gt;&#xA;        &lt;td valign=&quot;top&quot;&gt;&#xA;          &lt;a name=&quot;NWO_5_2098&quot; target=&quot;_blank&quot; href=&quot;/cgi/entity_page.cgi?term=100&amp;id=2098&quot;&gt;Smac/Diablo&lt;/a&gt;&#xA;        &lt;/td&gt;&#xA;        &lt;td&gt;&#xA;          Diablo homolog, mitochondrial&#xA;        &lt;/td&gt;&#xA;      &lt;/tr&gt;&#xA;      &lt;tr&gt;&#xA;        &lt;td valign=&quot;top&quot;&gt;&#xA;          &lt;a name=&quot;NWO_5_765&quot; target=&quot;_blank&quot; href=&quot;/cgi/entity_page.cgi?term=100&amp;id=765&quot;&gt;TNF-R1&lt;/a&gt;&#xA;        &lt;/td&gt;&#xA;        &lt;td&gt;&#xA;          Tumor necrosis factor receptor superfamily member 1A&#xA;        &lt;/td&gt;&#xA;      &lt;/tr&gt;&#xA;      &lt;tr&gt;&#xA;        &lt;td valign=&quot;top&quot;&gt;&#xA;          &lt;a name=&quot;NWO_5_-891482124&quot; target=&quot;_blank&quot; href=&quot;/cgi/entity_page.cgi?term=100&amp;id=-891482124&quot;&gt;VDAC &#xA;          1&lt;/a&gt;&#xA;        &lt;/td&gt;&#xA;        &lt;td&gt;&#xA;          Voltage-dependent anion-selective channel protein 1&#xA;        &lt;/td&gt;&#xA;      &lt;/tr&gt;&#xA;      &lt;tr&gt;&#xA;        &lt;td valign=&quot;top&quot;&gt;&#xA;          &lt;a name=&quot;NWO_5_-478261683&quot; target=&quot;_blank&quot; href=&quot;/cgi/entity_page.cgi?term=100&amp;id=-478261683&quot;&gt;VDAC &#xA;          2&lt;/a&gt;&#xA;        &lt;/td&gt;&#xA;        &lt;td&gt;&#xA;          Voltage-dependent anion-selective channel protein 2&#xA;        &lt;/td&gt;&#xA;      &lt;/tr&gt;&#xA;      &lt;tr&gt;&#xA;        &lt;td valign=&quot;top&quot;&gt;&#xA;          &lt;a name=&quot;NWO_5_886&quot; target=&quot;_blank&quot; href=&quot;/cgi/entity_page.cgi?term=100&amp;id=886&quot;&gt;c-Raf-1&lt;/a&gt;&#xA;        &lt;/td&gt;&#xA;        &lt;td&gt;&#xA;          RAF proto-oncogene serine/threonine-protein kinase&#xA;        &lt;/td&gt;&#xA;      &lt;/tr&gt;&#xA;      &lt;tr&gt;&#xA;        &lt;td valign=&quot;top&quot;&gt;&#xA;          &lt;a name=&quot;NWO_5_-429333329&quot; target=&quot;_blank&quot; href=&quot;/cgi/entity_page.cgi?term=100&amp;id=-429333329&quot;&gt;tBid&lt;/a&gt;&#xA;        &lt;/td&gt;&#xA;        &lt;td&gt;&#xA;          Truncated BH3-interacting domain death agonist&#xA;        &lt;/td&gt;&#xA;      &lt;/tr&gt;&#xA;    &lt;/table&gt;&#xA;    &lt;br&gt;&#xA;    &lt;br&gt;&#xA;    &#xA;&#xA;    &lt;h2&gt;&#xA;      References&#xA;    &lt;/h2&gt;&#xA;    &lt;ol&gt;&#xA;      &lt;li id=&quot;PBM_5_15640619&quot;&gt;&#xA;        Khosravi-Far R, Esposti MD&lt;br&gt;&lt;a target=&quot;_blank&quot; href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/15640619?dopt=Abstract&quot;&gt;Death &#xA;        receptor signals to mitochondria.&lt;/a&gt; Cancer biology &amp;amp; therapy 2004 &#xA;        Nov;3(11):1051-7&#xA;      &lt;/li&gt;&#xA;      &lt;li id=&quot;PBM_5_15706096&quot;&gt;&#xA;        Shakibaei M, Schulze-Tanzil G, Takada Y, Aggarwal BB&lt;br&gt;&lt;a target=&quot;_blank&quot; href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/15706096?dopt=Abstract&quot;&gt;Redox &#xA;        regulation of apoptosis by members of the TNF superfamily.&lt;/a&gt; &#xA;        Antioxidants &amp;amp; redox signaling 2005 Mar-Apr;7(3-4):482-96&#xA;      &lt;/li&gt;&#xA;      &lt;li id=&quot;PBM_5_9337844&quot;&gt;&#xA;        Cohen GM&lt;br&gt;&lt;a target=&quot;_blank&quot; href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/9337844?dopt=Abstract&quot;&gt;Caspases: &#xA;        the executioners of apoptosis.&lt;/a&gt; The Biochemical journal 1997 Aug &#xA;        15;326 ( Pt 1):1-16&#xA;      &lt;/li&gt;&#xA;      &lt;li id=&quot;PBM_5_10235259&quot;&gt;&#xA;        Imai Y, Kimura T, Murakami A, Yajima N, Sakamaki K, Yonehara S&lt;br&gt;&lt;a target=&quot;_blank&quot; href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/10235259?dopt=Abstract&quot;&gt;The &#xA;        CED-4-homologous protein FLASH is involved in Fas-mediated activation &#xA;        of caspase-8 during apoptosis.&lt;/a&gt; Nature 1999 Apr 29;398(6730):777-85&#xA;      &lt;/li&gt;&#xA;      &lt;li id=&quot;PBM_5_11175253&quot;&gt;&#xA;        Korsmeyer SJ, Wei MC, Saito M, Weiler S, Oh KJ, Schlesinger PH&lt;br&gt;&lt;a target=&quot;_blank&quot; href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/11175253?dopt=Abstract&quot;&gt;Pro-apoptotic &#xA;        cascade activates BID, which oligomerizes BAK or BAX into pores that &#xA;        result in the release of cytochrome c.&lt;/a&gt; Cell death and &#xA;        differentiation 2000 Dec;7(12):1166-73&#xA;      &lt;/li&gt;&#xA;      &lt;li id=&quot;PBM_5_15123718&quot;&gt;&#xA;        Gong XM, Choi J, Franzin CM, Zhai D, Reed JC, Marassi FM&lt;br&gt;&lt;a target=&quot;_blank&quot; href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/15123718?dopt=Abstract&quot;&gt;Conformation &#xA;        of membrane-associated proapoptotic tBid.&lt;/a&gt; The Journal of &#xA;        biological chemistry 2004 Jul 9;279(28):28954-60&#xA;      &lt;/li&gt;&#xA;      &lt;li id=&quot;PBM_5_11402069&quot;&gt;&#xA;        Nechushtan A, Smith CL, Lamensdorf I, Yoon SH, Youle RJ&lt;br&gt;&lt;a target=&quot;_blank&quot; href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/11402069?dopt=Abstract&quot;&gt;Bax &#xA;        and Bak coalesce into novel mitochondria-associated clusters during &#xA;        apoptosis.&lt;/a&gt; The Journal of cell biology 2001 Jun 11;153(6):1265-76&#xA;      &lt;/li&gt;&#xA;      &lt;li id=&quot;PBM_5_12454021&quot;&gt;&#xA;        Mikhailov V, Mikhailova M, Degenhardt K, Venkatachalam MA, White E, &#xA;        Saikumar P&lt;br&gt;&lt;a target=&quot;_blank&quot; href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/12454021?dopt=Abstract&quot;&gt;Association &#xA;        of Bax and Bak homo-oligomers in mitochondria. Bax requirement for Bak &#xA;        reorganization and cytochrome c release.&lt;/a&gt; The Journal of biological &#xA;        chemistry 2003 Feb 14;278(7):5367-76&#xA;      &lt;/li&gt;&#xA;      &lt;li id=&quot;PBM_5_11805084&quot;&gt;&#xA;        Grinberg M, Sarig R, Zaltsman Y, Frumkin D, Grammatikakis N, Reuveny &#xA;        E, Gross A&lt;br&gt;&lt;a target=&quot;_blank&quot; href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/11805084?dopt=Abstract&quot;&gt;tBID &#xA;        Homooligomerizes in the mitochondrial membrane to induce apoptosis.&lt;/a&gt; &#xA;        The Journal of biological chemistry 2002 Apr 5;277(14):12237-45&#xA;      &lt;/li&gt;&#xA;      &lt;li id=&quot;PBM_5_10934477&quot;&gt;&#xA;        Saito M, Korsmeyer SJ, Schlesinger PH&lt;br&gt;&lt;a target=&quot;_blank&quot; href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/10934477?dopt=Abstract&quot;&gt;BAX-dependent &#xA;        transport of cytochrome c reconstituted in pure liposomes.&lt;/a&gt; Nature &#xA;        cell biology 2000 Aug;2(8):553-5&#xA;      &lt;/li&gt;&#xA;      &lt;li id=&quot;PBM_5_11964312&quot;&gt;&#xA;        Guo F, Nimmanapalli R, Paranawithana S, Wittman S, Griffin D, Bali P, &#xA;        O'Bryan E, Fumero C, Wang HG, Bhalla K&lt;br&gt;&lt;a target=&quot;_blank&quot; href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/11964312?dopt=Abstract&quot;&gt;Ectopic &#xA;        overexpression of second mitochondria-derived activator of caspases &#xA;        (Smac/DIABLO) or cotreatment with N-terminus of Smac/DIABLO peptide &#xA;        potentiates epothilone B derivative-(BMS 247550) and &#xA;        Apo-2L/TRAIL-induced apoptosis.&lt;/a&gt; Blood 2002 May 1;99(9):3419-26&#xA;      &lt;/li&gt;&#xA;      &lt;li id=&quot;PBM_5_15800609&quot;&gt;&#xA;        Halestrap A&lt;br&gt;&lt;a target=&quot;_blank&quot; href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/15800609?dopt=Abstract&quot;&gt;Biochemistry: &#xA;        a pore way to die.&lt;/a&gt; Nature 2005 Mar 31;434(7033):578-9&#xA;      &lt;/li&gt;&#xA;      &lt;li id=&quot;PBM_5_9390557&quot;&gt;&#xA;        Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES, &#xA;        Wang X&lt;br&gt;&lt;a target=&quot;_blank&quot; href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/9390557?dopt=Abstract&quot;&gt;Cytochrome &#xA;        c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates &#xA;        an apoptotic protease cascade.&lt;/a&gt; Cell 1997 Nov 14;91(4):479-89&#xA;      &lt;/li&gt;&#xA;      &lt;li id=&quot;PBM_5_10809232&quot;&gt;&#xA;        Yan W, Samson M, J&amp;#233;gou B, Toppari J&lt;br&gt;&lt;a target=&quot;_blank&quot; href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/10809232?dopt=Abstract&quot;&gt;Bcl-w &#xA;        forms complexes with Bax and Bak, and elevated ratios of Bax/Bcl-w and &#xA;        Bak/Bcl-w correspond to spermatogonial and spermatocyte apoptosis in &#xA;        the testis.&lt;/a&gt; Molecular endocrinology (Baltimore, Md.) 2000 &#xA;        May;14(5):682-99&#xA;      &lt;/li&gt;&#xA;      &lt;li id=&quot;PBM_5_11278245&quot;&gt;&#xA;        Ke N, Godzik A, Reed JC&lt;br&gt;&lt;a target=&quot;_blank&quot; href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/11278245?dopt=Abstract&quot;&gt;Bcl-B, &#xA;        a novel Bcl-2 family member that differentially binds and regulates &#xA;        Bax and Bak.&lt;/a&gt; The Journal of biological chemistry 2001 Apr &#xA;        20;276(16):12481-4&#xA;      &lt;/li&gt;&#xA;      &lt;li id=&quot;PBM_5_12135371&quot;&gt;&#xA;        Shangary S, Johnson DE&lt;br&gt;&lt;a target=&quot;_blank&quot; href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/12135371?dopt=Abstract&quot;&gt;Peptides &#xA;        derived from BH3 domains of Bcl-2 family members: a comparative &#xA;        analysis of inhibition of Bcl-2, Bcl-x(L) and Bax oligomerization, &#xA;        induction of cytochrome c release, and activation of cell death.&lt;/a&gt; &#xA;        Biochemistry 2002 Jul 30;41(30):9485-95&#xA;      &lt;/li&gt;&#xA;      &lt;li id=&quot;PBM_5_12721291&quot;&gt;&#xA;        Ruffolo SC, Shore GC&lt;br&gt;&lt;a target=&quot;_blank&quot; href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/12721291?dopt=Abstract&quot;&gt;BCL-2 &#xA;        selectively interacts with the BID-induced open conformer of BAK, &#xA;        inhibiting BAK auto-oligomerization.&lt;/a&gt; The Journal of biological &#xA;        chemistry 2003 Jul 4;278(27):25039-45&#xA;      &lt;/li&gt;&#xA;      &lt;li id=&quot;PBM_5_12732850&quot;&gt;&#xA;        Guo B, Zhai D, Cabezas E, Welsh K, Nouraini S, Satterthwait AC, Reed JC&lt;br&gt;&lt;a target=&quot;_blank&quot; href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/12732850?dopt=Abstract&quot;&gt;Humanin &#xA;        peptide suppresses apoptosis by interfering with Bax activation.&lt;/a&gt; &#xA;        Nature 2003 May 22;423(6938):456-61&#xA;      &lt;/li&gt;&#xA;      &lt;li id=&quot;PBM_5_15694340&quot;&gt;&#xA;        Chen L, Willis SN, Wei A, Smith BJ, Fletcher JI, Hinds MG, Colman PM, &#xA;        Day CL, Adams JM, Huang DC&lt;br&gt;&lt;a target=&quot;_blank&quot; href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/15694340?dopt=Abstract&quot;&gt;Differential &#xA;        targeting of prosurvival Bcl-2 proteins by their BH3-only ligands &#xA;        allows complementary apoptotic function.&lt;/a&gt; Molecular cell 2005 Feb &#xA;        4;17(3):393-403&#xA;      &lt;/li&gt;&#xA;      &lt;li id=&quot;PBM_5_15077142&quot;&gt;&#xA;        Cregan SP, Dawson VL, Slack RS&lt;br&gt;&lt;a target=&quot;_blank&quot; href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/15077142?dopt=Abstract&quot;&gt;Role &#xA;        of AIF in caspase-dependent and caspase-independent cell death.&lt;/a&gt; &#xA;        Oncogene 2004 Apr 12;23(16):2785-96&#xA;      &lt;/li&gt;&#xA;    &lt;/ol&gt;&#xA;  &lt;/body&gt;&#xA;&lt;/html&gt;&#xA;&lt;!--MapId=5--&gt;&#xA;" map_type="0" mapOrgType="0" Format="4" inner_loc="1">
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      <alt>Object &lt;b&gt;VDAC 2&lt;/b&gt;:&lt;br/&gt;Voltage-dependent anion-selective channel protein 2 &lt;i&gt;Protein (Homo sapiens)&lt;/i&gt;&lt;br/&gt;Voltage-dependent anion-selective channel protein 2 &lt;i&gt;Protein (Mus musculus)&lt;/i&gt;&lt;br/&gt;Voltage-dependent anion-selective channel protein 2 &lt;i&gt;Protein (Rattus norvegicus)&lt;/i&gt;</alt>
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      <alt>Object &lt;b&gt;Aif&lt;/b&gt;:&lt;br/&gt;Apoptosis-inducing factor 1, mitochondrial &lt;i&gt;Protein (Homo sapiens)&lt;/i&gt;&lt;br/&gt;Apoptosis-inducing factor 1, mitochondrial &lt;i&gt;Protein (Mus musculus)&lt;/i&gt;&lt;br/&gt;Apoptosis-inducing factor 1, mitochondrial &lt;i&gt;Protein (Rattus norvegicus)&lt;/i&gt;</alt>
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      <alt>Object &lt;b&gt;ANT&lt;/b&gt;:&lt;br/&gt;Adenine nucleotide translocases &lt;i&gt;Protein group (Homo sapiens)&lt;/i&gt;&lt;br/&gt;Adenine nucleotide translocases &lt;i&gt;Protein group (Mus musculus)&lt;/i&gt;&lt;br/&gt;Adenine nucleotide translocases &lt;i&gt;Protein group (Rattus norvegicus)&lt;/i&gt;</alt>
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    <node type="0" name="BAD" url="/cgi/entity_page.cgi?id=71&amp;term=100" id="71" nodeid="291" x="202" y="715" width="68" height="101" icontype="58" complex="false" netwobj="0" bindLoc="1287">
      <alt>Object &lt;b&gt;BAD&lt;/b&gt;:&lt;br/&gt;Bcl2 antagonist of cell death &lt;i&gt;Protein (Homo sapiens)&lt;/i&gt;&lt;br/&gt;Bcl2 antagonist of cell death &lt;i&gt;Protein (Mus musculus)&lt;/i&gt;&lt;br/&gt;Bcl2 antagonist of cell death &lt;i&gt;Protein (Rattus norvegicus)&lt;/i&gt;</alt>
      <Appearance TextArea="Rectangle: 222, 763, 29, 16" IconArea="Rectangle: 225, 731, 23, 37" RotateAngle="Integer: 0" ZOrder="Integer: 28" TextAlignment="Integer: 0" LinkPointCount="Integer: 3" LinkPointMargin="Integer: 0" PathStart="Boolean: true" SideofPathStartEditor="Integer: 2" PathStartArrowMargin="Integer: 7" OrganismSpecificObject="Boolean: false" Comlex="Boolean: false" Font="Font:Arial,0,12" />
    </node>
    <node type="0" name="Bcl-2" url="/cgi/entity_page.cgi?id=86&amp;term=100" id="86" nodeid="192" x="50" y="418" width="68" height="68" icontype="58" complex="false" netwobj="0" bindLoc="1287">
      <alt>Object &lt;b&gt;Bcl-2&lt;/b&gt;:&lt;br/&gt;Apoptosis regulator Bcl-2 &lt;i&gt;Protein (Homo sapiens)&lt;/i&gt;&lt;br/&gt;Apoptosis regulator Bcl-2 &lt;i&gt;Protein (Mus musculus)&lt;/i&gt;&lt;br/&gt;Apoptosis regulator Bcl-2 &lt;i&gt;Protein (Rattus norvegicus)&lt;/i&gt;</alt>
      <Appearance TextArea="Rectangle: 68, 466, 33, 16" IconArea="Rectangle: 73, 434, 23, 37" RotateAngle="Integer: 0" ZOrder="Integer: 40" TextAlignment="Integer: 0" LinkPointCount="Integer: 33" LinkPointMargin="Integer: 0" PathStart="Boolean: false" SideofPathStartEditor="Integer: 0" PathStartArrowMargin="Integer: 7" OrganismSpecificObject="Boolean: false" Comlex="Boolean: false" Font="Font:Arial,0,12" />
    </node>
    <node type="0" name="BIM" url="/cgi/entity_page.cgi?id=4039&amp;term=100" id="4039" nodeid="270" x="289" y="742" width="68" height="101" icontype="58" complex="false" netwobj="0" bindLoc="16">
      <alt>Object &lt;b&gt;Bim&lt;/b&gt;:&lt;br/&gt;Bcl-2-like protein 11 &lt;i&gt;Protein (Homo sapiens)&lt;/i&gt;&lt;br/&gt;Bcl-2-like protein 11 &lt;i&gt;Protein (Mus musculus)&lt;/i&gt;&lt;br/&gt;Bcl-2-like protein 11 &lt;i&gt;Protein (Rattus norvegicus)&lt;/i&gt;</alt>
      <Appearance TextArea="Rectangle: 311, 790, 25, 16" IconArea="Rectangle: 312, 758, 23, 37" RotateAngle="Integer: 0" ZOrder="Integer: 64" TextAlignment="Integer: 0" LinkPointCount="Integer: 33" LinkPointMargin="Integer: 0" PathStart="Boolean: true" SideofPathStartEditor="Integer: 2" PathStartArrowMargin="Integer: 7" OrganismSpecificObject="Boolean: false" Comlex="Boolean: false" Font="Font:Arial,0,12" />
    </node>
    <node type="21" name="Regulation of apoptosis" url="/cgi/process.cgi?id=-1464607230" id="-1464607230" nodeid="ll21akkf69kf7a-164j490l25l4a5f" x="824" y="8" width="113" height="50" icontype="1" complex="false" netwobj="0" bindLoc="0">
      <alt>Any process that modulates the occurrence or rate of cell death by apoptotic process.</alt>
      <Appearance TextArea="Rectangle: 832, 16, 97, 34" IconArea="Rectangle: 824, 8, 113, 50" RotateAngle="Integer: 0" ZOrder="Integer: 8" TextAlignment="Integer: 1" LinkPointCount="Integer: 100" LinkPointMargin="Integer: 0" PathStart="Boolean: false" SideofPathStartEditor="Integer: 0" PathStartArrowMargin="Integer: 7" OrganismSpecificObject="Boolean: false" Comlex="Boolean: false" Font="Font:Arial,0,14" ArcWidth="Integer: 20" ArcHeight="Integer: 20" BackgroundColor="Color:102,102,255,255" BorderWidth="Integer: 4" BorderColor="Color:0,0,153,255" FontColor="Color:255,255,255,255" />
    </node>
    <node type="16" name="TNFR1 signaling pathway" url="/cgi/imagemap.cgi?id=420" id="420" nodeid="593" x="254" y="41" width="138" height="58" icontype="56" complex="false" netwobj="0" bindLoc="0">
      <alt>Apoptosis and survival_TNFR1 signaling pathway</alt>
      <Appearance TextArea="Rectangle: 254, 75, 138, 16" IconArea="Rectangle: 332, 60, 27, 20" RotateAngle="Integer: 0" ZOrder="Integer: 80" TextAlignment="Integer: 0" LinkPointCount="Integer: 3" LinkPointMargin="Integer: 0" PathStart="Boolean: false" SideofPathStartEditor="Integer: 0" PathStartArrowMargin="Integer: 7" OrganismSpecificObject="Boolean: false" Comlex="Boolean: false" Font="Font:Arial,0,12" />
    </node>
    <node type="0" name="Apaf-1" url="/cgi/entity_page.cgi?id=60&amp;term=100" id="60" nodeid="133" x="750" y="136" width="68" height="68" icontype="58" complex="false" netwobj="0" bindLoc="1">
      <alt>Object &lt;b&gt;Apaf-1&lt;/b&gt;:&lt;br/&gt;Apoptotic protease-activating factor 1 &lt;i&gt;Protein (Homo sapiens)&lt;/i&gt;&lt;br/&gt;Apoptotic protease-activating factor 1 &lt;i&gt;Protein (Mus musculus)&lt;/i&gt;&lt;br/&gt;Apoptotic protease-activating factor 1 &lt;i&gt;Protein (Rattus norvegicus)&lt;/i&gt;</alt>
      <Appearance TextArea="Rectangle: 765, 184, 40, 16" IconArea="Rectangle: 773, 152, 23, 37" RotateAngle="Integer: 0" ZOrder="Integer: 26" TextAlignment="Integer: 0" LinkPointCount="Integer: 3" LinkPointMargin="Integer: 0" PathStart="Boolean: false" SideofPathStartEditor="Integer: 0" PathStartArrowMargin="Integer: 7" OrganismSpecificObject="Boolean: false" Comlex="Boolean: false" Font="Font:Arial,0,12" />
    </node>
    <node type="0" name="TNF-R1" url="/cgi/entity_page.cgi?id=765&amp;term=100" id="765" nodeid="573" x="140" y="9" width="72" height="97" icontype="10" complex="false" netwobj="0" bindLoc="16">
      <alt>Object &lt;b&gt;TNF-R1&lt;/b&gt;:&lt;br/&gt;Tumor necrosis factor receptor superfamily member 1A &lt;i&gt;Protein (Homo sapiens)&lt;/i&gt;&lt;br/&gt;Tumor necrosis factor receptor superfamily member 1A &lt;i&gt;Protein (Mus musculus)&lt;/i&gt;&lt;br/&gt;Tumor necrosis factor receptor superfamily member 1A &lt;i&gt;Protein (Rattus norvegicus)&lt;/i&gt;</alt>
      <Appearance TextArea="Rectangle: 154, 86, 48, 16" IconArea="Rectangle: 161, 52, 30, 37" RotateAngle="Integer: 0" ZOrder="Integer: 50" TextAlignment="Integer: 0" LinkPointCount="Integer: 3" LinkPointMargin="Integer: 0" PathStart="Boolean: true" SideofPathStartEditor="Integer: 0" PathStartArrowMargin="Integer: 1" OrganismSpecificObject="Boolean: false" Comlex="Boolean: false" Font="Font:Arial,0,12" />
    </node>
    <node type="0" name="c-Raf-1" url="/cgi/entity_page.cgi?id=886&amp;term=100" id="886" nodeid="331" x="28" y="240" width="76" height="76" icontype="61" complex="false" netwobj="0" bindLoc="1">
      <alt>Object &lt;b&gt;c-Raf-1&lt;/b&gt;:&lt;br/&gt;RAF proto-oncogene serine/threonine-protein kinase &lt;i&gt;Protein (Homo sapiens)&lt;/i&gt;&lt;br/&gt;RAF proto-oncogene serine/threonine-protein kinase &lt;i&gt;Protein (Mus musculus)&lt;/i&gt;&lt;br/&gt;RAF proto-oncogene serine/threonine-protein kinase &lt;i&gt;Protein (Rattus norvegicus)&lt;/i&gt;</alt>
      <Appearance TextArea="Rectangle: 43, 288, 45, 16" IconArea="Rectangle: 45, 263, 42, 30" RotateAngle="Integer: 0" ZOrder="Integer: 52" TextAlignment="Integer: 0" LinkPointCount="Integer: 3" LinkPointMargin="Integer: 0" PathStart="Boolean: false" SideofPathStartEditor="Integer: 3" PathStartArrowMargin="Integer: 1" OrganismSpecificObject="Boolean: false" Comlex="Boolean: false" Font="Font:Arial,0,12" />
    </node>
    <node type="16" name="FAS signaling cascades" url="/cgi/imagemap.cgi?id=418" id="418" nodeid="596" x="547" y="41" width="129" height="58" icontype="56" complex="false" netwobj="0" bindLoc="0">
      <alt>Apoptosis and survival_FAS signaling cascades</alt>
      <Appearance TextArea="Rectangle: 547, 77, 129, 16" IconArea="Rectangle: 595, 60, 27, 20" RotateAngle="Integer: 0" ZOrder="Integer: 78" TextAlignment="Integer: 0" LinkPointCount="Integer: 3" LinkPointMargin="Integer: 0" PathStart="Boolean: false" SideofPathStartEditor="Integer: 0" PathStartArrowMargin="Integer: 7" OrganismSpecificObject="Boolean: false" Comlex="Boolean: false" Font="Font:Arial,0,12" />
    </node>
    <node type="0" name="Bcl-B" url="/cgi/entity_page.cgi?id=-1291709962&amp;term=100" id="-1291709962" nodeid="113" x="31" y="544" width="68" height="101" icontype="58" complex="false" netwobj="0" bindLoc="1">
      <alt>Object &lt;b&gt;Bcl-B&lt;/b&gt;:&lt;br/&gt;Bcl-2-like protein 10 &lt;i&gt;Protein (Homo sapiens)&lt;/i&gt;&lt;br/&gt;Bcl-2-like protein 10 &lt;i&gt;Protein (Mus musculus)&lt;/i&gt;&lt;br/&gt;Bcl-2-like protein 10 &lt;i&gt;Protein (Rattus norvegicus)&lt;/i&gt;</alt>
      <Appearance TextArea="Rectangle: 49, 592, 34, 16" IconArea="Rectangle: 54, 560, 23, 37" RotateAngle="Integer: 0" ZOrder="Integer: 16" TextAlignment="Integer: 0" LinkPointCount="Integer: 33" LinkPointMargin="Integer: 0" PathStart="Boolean: true" SideofPathStartEditor="Integer: 2" PathStartArrowMargin="Integer: 7" OrganismSpecificObject="Boolean: false" Comlex="Boolean: false" Font="Font:Arial,0,12" />
    </node>
    <node type="0" name="Bid" url="/cgi/entity_page.cgi?id=88&amp;term=100" id="88" nodeid="157" x="600" y="203" width="68" height="68" icontype="58" complex="false" netwobj="0" bindLoc="1">
      <alt>Object &lt;b&gt;Bid&lt;/b&gt;:&lt;br/&gt;BH3-interacting domain death agonist &lt;i&gt;Protein (Homo sapiens)&lt;/i&gt;&lt;br/&gt;BH3-interacting domain death agonist &lt;i&gt;Protein (Mus musculus)&lt;/i&gt;&lt;br/&gt;BH3-interacting domain death agonist &lt;i&gt;Protein (Rattus norvegicus)&lt;/i&gt;</alt>
      <Appearance TextArea="Rectangle: 639, 253, 18, 16" IconArea="Rectangle: 623, 219, 23, 37" RotateAngle="Integer: 0" ZOrder="Integer: 44" TextAlignment="Integer: 0" LinkPointCount="Integer: 3" LinkPointMargin="Integer: 0" PathStart="Boolean: false" SideofPathStartEditor="Integer: 0" PathStartArrowMargin="Integer: 7" OrganismSpecificObject="Boolean: false" Comlex="Boolean: false" Font="Font:Arial,0,12" />
    </node>
    <node type="0" name="MAP1" url="/cgi/entity_page.cgi?id=4050&amp;term=100" id="4050" nodeid="355" x="721" y="686" width="68" height="101" icontype="58" complex="false" netwobj="0" bindLoc="1">
      <alt>Object &lt;b&gt;MAP1&lt;/b&gt;:&lt;br/&gt;Modulator of apoptosis 1 &lt;i&gt;Protein (Homo sapiens)&lt;/i&gt;&lt;br/&gt;Modulator of apoptosis 1 &lt;i&gt;Protein (Mus musculus)&lt;/i&gt;&lt;br/&gt;modulator of apoptosis 1 &lt;i&gt;Protein (Rattus norvegicus)&lt;/i&gt;</alt>
      <Appearance TextArea="Rectangle: 738, 734, 36, 16" IconArea="Rectangle: 744, 702, 23, 37" RotateAngle="Integer: 0" ZOrder="Integer: 72" TextAlignment="Integer: 0" LinkPointCount="Integer: 33" LinkPointMargin="Integer: 0" PathStart="Boolean: true" SideofPathStartEditor="Integer: 2" PathStartArrowMargin="Integer: 7" OrganismSpecificObject="Boolean: false" Comlex="Boolean: false" Font="Font:Arial,0,12" />
    </node>
    <node type="16" name="BAD phosphorylation" url="/cgi/imagemap.cgi?id=661" id="661" nodeid="554" x="23" y="135" width="98" height="67" icontype="56" complex="false" netwobj="0" bindLoc="0">
      <alt>Apoptosis and survival_BAD phosphorylation</alt>
      <Appearance TextArea="Rectangle: 23, 160, 98, 42" IconArea="Rectangle: 53, 154, 27, 20" RotateAngle="Integer: 0" ZOrder="Integer: 84" TextAlignment="Integer: 0" LinkPointCount="Integer: 3" LinkPointMargin="Integer: 0" PathStart="Boolean: false" SideofPathStartEditor="Integer: 0" PathStartArrowMargin="Integer: 7" OrganismSpecificObject="Boolean: false" Comlex="Boolean: false" Font="Font:Arial,0,12" />
    </node>
    <node type="0" name="BFL1" url="/cgi/entity_page.cgi?id=-1698772377&amp;term=100" id="-1698772377" nodeid="215" x="795" y="480" width="73" height="68" icontype="58" complex="false" netwobj="0" bindLoc="1">
      <alt>Object &lt;b&gt;BFL1&lt;/b&gt;:&lt;br/&gt;Bcl-2-related protein A1 &lt;i&gt;Protein (Homo sapiens)&lt;/i&gt;&lt;br/&gt;Bcl-2-related protein A1 &lt;i&gt;Protein (Mus musculus)&lt;/i&gt;&lt;br/&gt;B-cell leukemia/lymphoma 2 related protein A1 &lt;i&gt;Protein (Rattus norvegicus)&lt;/i&gt;</alt>
      <Appearance TextArea="Rectangle: 795, 503, 34, 16" IconArea="Rectangle: 823, 496, 23, 37" RotateAngle="Integer: 0" ZOrder="Integer: 12" TextAlignment="Integer: 0" LinkPointCount="Integer: 33" LinkPointMargin="Integer: 0" PathStart="Boolean: false" SideofPathStartEditor="Integer: 0" PathStartArrowMargin="Integer: 7" OrganismSpecificObject="Boolean: false" Comlex="Boolean: false" Font="Font:Arial,0,12" />
    </node>
    <node type="0" name="NOXA" url="/cgi/entity_page.cgi?id=4047&amp;term=100" id="4047" nodeid="314" x="807" y="657" width="68" height="101" icontype="58" complex="false" netwobj="0" bindLoc="1287">
      <alt>Object &lt;b&gt;NOXA&lt;/b&gt;:&lt;br/&gt;Phorbol-12-myristate-13-acetate-induced protein 1 &lt;i&gt;Protein (Homo sapiens)&lt;/i&gt;&lt;br/&gt;Phorbol-12-myristate-13-acetate-induced protein 1 &lt;i&gt;Protein (Mus musculus)&lt;/i&gt;&lt;br/&gt;Phorbol-12-myristate-13-acetate-induced protein 1 &lt;i&gt;Protein (Rattus norvegicus)&lt;/i&gt;</alt>
      <Appearance TextArea="Rectangle: 823, 705, 37, 16" IconArea="Rectangle: 830, 673, 23, 37" RotateAngle="Integer: 0" ZOrder="Integer: 68" TextAlignment="Integer: 0" LinkPointCount="Integer: 3" LinkPointMargin="Integer: 0" PathStart="Boolean: true" SideofPathStartEditor="Integer: 2" PathStartArrowMargin="Integer: 7" OrganismSpecificObject="Boolean: false" Comlex="Boolean: false" Font="Font:Arial,0,12" />
    </node>
    <node type="0" name="IGF-1 receptor" url="/cgi/entity_page.cgi?id=381&amp;term=100" id="381" nodeid="557" x="25" y="6" width="83" height="104" icontype="15" complex="false" netwobj="0" bindLoc="16">
      <alt>Object &lt;b&gt;IGF-1 receptor&lt;/b&gt;:&lt;br/&gt;Insulin-like growth factor 1 receptor &lt;i&gt;Protein (Homo sapiens)&lt;/i&gt;&lt;br/&gt;Insulin-like growth factor 1 receptor &lt;i&gt;Protein (Mus musculus)&lt;/i&gt;&lt;br/&gt;Insulin-like growth factor 1 receptor &lt;i&gt;Protein (Rattus norvegicus)&lt;/i&gt;</alt>
      <Appearance TextArea="Rectangle: 25, 87, 83, 16" IconArea="Rectangle: 49, 49, 34, 43" RotateAngle="Integer: 0" ZOrder="Integer: 48" TextAlignment="Integer: 0" LinkPointCount="Integer: 3" LinkPointMargin="Integer: 0" PathStart="Boolean: true" SideofPathStartEditor="Integer: 0" PathStartArrowMargin="Integer: 1" OrganismSpecificObject="Boolean: false" Comlex="Boolean: false" Font="Font:Arial,0,12" />
    </node>
    <node type="0" name="Cytochrome c" url="/cgi/entity_page.cgi?id=934&amp;term=100" id="934" nodeid="238" x="511" y="109" width="86" height="78" icontype="2" complex="false" netwobj="0" bindLoc="1287">
      <alt>Object &lt;b&gt;Cytochrome c&lt;/b&gt;:&lt;br/&gt;Cytochrome c &lt;i&gt;Protein (Homo sapiens)&lt;/i&gt;&lt;br/&gt;Cytochrome c, somatic &lt;i&gt;Protein (Mus musculus)&lt;/i&gt;&lt;br/&gt;Cytochrome c, somatic &lt;i&gt;Protein (Rattus norvegicus)&lt;/i&gt;</alt>
      <Appearance TextArea="Rectangle: 518, 160, 79, 25" IconArea="Rectangle: 529, 133, 42, 31" RotateAngle="Integer: 0" ZOrder="Integer: 58" TextAlignment="Integer: 0" LinkPointCount="Integer: 3" LinkPointMargin="Integer: 0" PathStart="Boolean: false" SideofPathStartEditor="Integer: 0" PathStartArrowMargin="Integer: 7" OrganismSpecificObject="Boolean: false" Comlex="Boolean: false" Font="Font:Arial,0,12" />
    </node>
    <node type="-11" name="Release from mitochondria" id="-1" nodeid="-k079g4l1iie581-l8c00jdg3i691k" x="497" y="253" width="107" height="48" icontype="1" complex="false" netwobj="0" bindLoc="0">
      <alt />
      <Appearance TextArea="Rectangle: 505, 261, 91, 32" IconArea="Rectangle: 497, 253, 107, 48" RotateAngle="Integer: 0" ZOrder="Integer: 10" TextAlignment="Integer: 1" LinkPointCount="Integer: 3" LinkPointMargin="Integer: 0" PathStart="Boolean: false" SideofPathStartEditor="Integer: 0" PathStartArrowMargin="Integer: 7" OrganismSpecificObject="Boolean: false" Comlex="Boolean: false" Font="Font:Arial,0,14" ArcWidth="Integer: 20" ArcHeight="Integer: 20" BackgroundColor="Color:102,102,255,255" BorderWidth="Integer: 4" BorderColor="Color:0,0,153,255" FontColor="Color:255,255,255,255" />
    </node>
    <node type="16" name="Caspase cascade" url="/cgi/imagemap.cgi?id=373" id="373" nodeid="e2h1cbccgadch3-k55gf20acf0bjd" x="851" y="69" width="73" height="92" icontype="56" complex="false" netwobj="0" bindLoc="0">
      <alt>Apoptosis and survival_Caspase cascade</alt>
      <Appearance TextArea="Rectangle: 864, 108, 60, 53" IconArea="Rectangle: 867, 88, 27, 20" RotateAngle="Integer: 0" ZOrder="Integer: 86" TextAlignment="Integer: 0" LinkPointCount="Integer: 3" LinkPointMargin="Integer: 0" PathStart="Boolean: false" SideofPathStartEditor="Integer: 0" PathStartArrowMargin="Integer: 7" OrganismSpecificObject="Boolean: false" Comlex="Boolean: false" Font="Font:Arial,0,12" />
    </node>
    <node type="0" name="Bak" url="/cgi/entity_page.cgi?id=84&amp;term=100" id="84" nodeid="59" x="211" y="243" width="66" height="66" icontype="46" complex="false" netwobj="0" bindLoc="1">
      <alt>Object &lt;b&gt;Bak&lt;/b&gt;:&lt;br/&gt;Bcl-2 homologous antagonist/killer &lt;i&gt;Protein (Homo sapiens)&lt;/i&gt;&lt;br/&gt;Bcl-2 homologous antagonist/killer &lt;i&gt;Protein (Mus musculus)&lt;/i&gt;&lt;br/&gt;BCL2-antagonist/killer 1 &lt;i&gt;Protein (Rattus norvegicus)&lt;/i&gt;</alt>
      <Appearance TextArea="Rectangle: 234, 290, 26, 16" IconArea="Rectangle: 233, 260, 23, 33" RotateAngle="Integer: 0" ZOrder="Integer: 30" TextAlignment="Integer: 0" LinkPointCount="Integer: 3" LinkPointMargin="Integer: 0" PathStart="Boolean: false" SideofPathStartEditor="Integer: 0" PathStartArrowMargin="Integer: 7" OrganismSpecificObject="Boolean: false" Comlex="Boolean: false" Font="Font:Arial,0,12" />
    </node>
    <node type="0" name="Bax" url="/cgi/entity_page.cgi?id=85&amp;term=100" id="85" nodeid="39" x="389" y="243" width="66" height="66" icontype="46" complex="false" netwobj="0" bindLoc="1">
      <alt>Object &lt;b&gt;Bax&lt;/b&gt;:&lt;br/&gt;Apoptosis regulator BAX &lt;i&gt;Protein (Homo sapiens)&lt;/i&gt;&lt;br/&gt;Apoptosis regulator BAX &lt;i&gt;Protein (Mus musculus)&lt;/i&gt;&lt;br/&gt;Apoptosis regulator BAX &lt;i&gt;Protein (Rattus norvegicus)&lt;/i&gt;</alt>
      <Appearance TextArea="Rectangle: 410, 288, 21, 16" IconArea="Rectangle: 411, 260, 23, 33" RotateAngle="Integer: 0" ZOrder="Integer: 38" TextAlignment="Integer: 0" LinkPointCount="Integer: 3" LinkPointMargin="Integer: 0" PathStart="Boolean: false" SideofPathStartEditor="Integer: 0" PathStartArrowMargin="Integer: 7" OrganismSpecificObject="Boolean: false" Comlex="Boolean: false" Font="Font:Arial,0,12" />
    </node>
    <node type="0" name="VDAC 1" url="/cgi/entity_page.cgi?id=-891482124&amp;term=100" id="-891482124" nodeid="19" x="275" y="243" width="86" height="66" icontype="46" complex="false" netwobj="0" bindLoc="16">
      <alt>Object &lt;b&gt;VDAC 1&lt;/b&gt;:&lt;br/&gt;Voltage-dependent anion-selective channel protein 1 &lt;i&gt;Protein (Homo sapiens)&lt;/i&gt;&lt;br/&gt;Voltage-dependent anion-selective channel protein 1 &lt;i&gt;Protein (Mus musculus)&lt;/i&gt;&lt;br/&gt;Voltage-dependent anion-selective channel protein 1 &lt;i&gt;Protein (Rattus norvegicus)&lt;/i&gt;</alt>
      <Appearance TextArea="Rectangle: 275, 276, 47, 16" IconArea="Rectangle: 317, 260, 23, 33" RotateAngle="Integer: 0" ZOrder="Integer: 18" TextAlignment="Integer: 0" LinkPointCount="Integer: 3" LinkPointMargin="Integer: 0" PathStart="Boolean: false" SideofPathStartEditor="Integer: 0" PathStartArrowMargin="Integer: 7" OrganismSpecificObject="Boolean: false" Comlex="Boolean: false" Font="Font:Arial,0,12" />
    </node>
    <node type="0" name="" url="/cgi/entity_page.cgi?id=-2034743228&amp;term=100" id="-2034743228" nodeid="2h2gd7cehklf39-193l30i86030093" x="663" y="208" width="58" height="58" icontype="54" complex="false" netwobj="0" bindLoc="0">
      <alt>Object &lt;b&gt;Bid = tBid&lt;/b&gt;:&lt;br/&gt;&lt;i&gt;Protein&lt;/i&gt;</alt>
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    </node>
    <node type="0" name="Caspase-8" url="/cgi/entity_page.cgi?id=914&amp;term=100" id="914" nodeid="181" x="430" y="110" width="76" height="76" icontype="5" complex="false" netwobj="0" bindLoc="1">
      <alt>Object &lt;b&gt;Caspase-8&lt;/b&gt;:&lt;br/&gt;Caspase-8 &lt;i&gt;Protein (Homo sapiens)&lt;/i&gt;&lt;br/&gt;Caspase-8 &lt;i&gt;Protein (Mus musculus)&lt;/i&gt;&lt;br/&gt;caspase 8 &lt;i&gt;Protein (Rattus norvegicus)&lt;/i&gt;</alt>
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    </node>
    <node type="0" name="Smac/Diablo" url="/cgi/entity_page.cgi?id=2098&amp;term=100" id="2098" nodeid="380" x="137" y="110" width="77" height="76" icontype="5" complex="false" netwobj="0" bindLoc="1287">
      <alt>Object &lt;b&gt;Smac/Diablo&lt;/b&gt;:&lt;br/&gt;Diablo homolog, mitochondrial &lt;i&gt;Protein (Homo sapiens)&lt;/i&gt;&lt;br/&gt;Diablo homolog, mitochondrial &lt;i&gt;Protein (Mus musculus)&lt;/i&gt;&lt;br/&gt;diablo homolog (Drosophila) &lt;i&gt;Protein (Rattus norvegicus)&lt;/i&gt;</alt>
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      <alt>Object &lt;b&gt;PUMA&lt;/b&gt;:&lt;br/&gt;Bcl-2-binding component 3 &lt;i&gt;Protein (Homo sapiens)&lt;/i&gt;&lt;br/&gt;Bcl-2-binding component 3 &lt;i&gt;Protein (Mus musculus)&lt;/i&gt;&lt;br/&gt;Bcl-2-binding component 3 &lt;i&gt;Protein (Rattus norvegicus)&lt;/i&gt;</alt>
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      <alt>Object &lt;b&gt;FasR(CD95)&lt;/b&gt;:&lt;br/&gt;Tumor necrosis factor receptor superfamily member 6 &lt;i&gt;Protein (Homo sapiens)&lt;/i&gt;&lt;br/&gt;Tumor necrosis factor receptor superfamily member 6 &lt;i&gt;Protein (Mus musculus)&lt;/i&gt;&lt;br/&gt;Tumor necrosis factor receptor superfamily member 6 &lt;i&gt;Protein (Rattus norvegicus)&lt;/i&gt;</alt>
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      <alt>Object &lt;b&gt;BMF&lt;/b&gt;:&lt;br/&gt;Bcl-2-modifying factor &lt;i&gt;Protein (Homo sapiens)&lt;/i&gt;&lt;br/&gt;Bcl-2-modifying factor &lt;i&gt;Protein (Mus musculus)&lt;/i&gt;&lt;br/&gt;Bcl-2-modifying factor &lt;i&gt;Protein (Rattus norvegicus)&lt;/i&gt;</alt>
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      <alt>Object &lt;b&gt;Bax&lt;/b&gt;:&lt;br/&gt;Apoptosis regulator BAX &lt;i&gt;Protein (Homo sapiens)&lt;/i&gt;&lt;br/&gt;Apoptosis regulator BAX &lt;i&gt;Protein (Mus musculus)&lt;/i&gt;&lt;br/&gt;Apoptosis regulator BAX &lt;i&gt;Protein (Rattus norvegicus)&lt;/i&gt;</alt>
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      <alt>Object &lt;b&gt;HRK&lt;/b&gt;:&lt;br/&gt;Activator of apoptosis harakiri &lt;i&gt;Protein (Homo sapiens)&lt;/i&gt;&lt;br/&gt;Activator of apoptosis harakiri &lt;i&gt;Protein (Mus musculus)&lt;/i&gt;&lt;br/&gt;Activator of apoptosis harakiri &lt;i&gt;Protein (Rattus norvegicus)&lt;/i&gt;</alt>
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      <alt>Object &lt;b&gt;Humanin&lt;/b&gt;:&lt;br/&gt;Putative humanin peptide &lt;i&gt;Protein (Homo sapiens)&lt;/i&gt;&lt;br/&gt;Putative humanin-like peptide &lt;i&gt;Protein (Rattus norvegicus)&lt;/i&gt;</alt>
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      <alt>Object &lt;b&gt;Bax&lt;/b&gt;:&lt;br/&gt;Apoptosis regulator BAX &lt;i&gt;Protein (Homo sapiens)&lt;/i&gt;&lt;br/&gt;Apoptosis regulator BAX &lt;i&gt;Protein (Mus musculus)&lt;/i&gt;&lt;br/&gt;Apoptosis regulator BAX &lt;i&gt;Protein (Rattus norvegicus)&lt;/i&gt;</alt>
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      <alt>Object &lt;b&gt;Bik&lt;/b&gt;:&lt;br/&gt;Bcl-2-interacting killer &lt;i&gt;Protein (Homo sapiens)&lt;/i&gt;&lt;br/&gt;Bcl2-interacting killer &lt;i&gt;Protein (Mus musculus)&lt;/i&gt;&lt;br/&gt;Bcl2-interacting killer &lt;i&gt;Protein (Rattus norvegicus)&lt;/i&gt;</alt>
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      <alt>Object &lt;b&gt;Mcl-1&lt;/b&gt;:&lt;br/&gt;Induced myeloid leukemia cell differentiation protein Mcl-1 &lt;i&gt;Protein (Homo sapiens)&lt;/i&gt;&lt;br/&gt;Induced myeloid leukemia cell differentiation protein Mcl-1 homolog &lt;i&gt;Protein (Mus musculus)&lt;/i&gt;&lt;br/&gt;Induced myeloid leukemia cell differentiation protein Mcl-1 homolog &lt;i&gt;Protein (Rattus norvegicus)&lt;/i&gt;</alt>
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      <alt>Object &lt;b&gt;Caspase-9&lt;/b&gt;:&lt;br/&gt;Caspase-9 &lt;i&gt;Protein (Homo sapiens)&lt;/i&gt;&lt;br/&gt;Caspase-9 &lt;i&gt;Protein (Mus musculus)&lt;/i&gt;&lt;br/&gt;Caspase 9 &lt;i&gt;Protein (Rattus norvegicus)&lt;/i&gt;</alt>
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      <alt>Object &lt;b&gt;tBid&lt;/b&gt;:&lt;br/&gt;Truncated BH3-interacting domain death agonist &lt;i&gt;Protein (Homo sapiens)&lt;/i&gt;&lt;br/&gt;tBid &lt;i&gt;Protein (Mus musculus)&lt;/i&gt;&lt;br/&gt;tBid &lt;i&gt;Protein (Rattus norvegicus)&lt;/i&gt;</alt>
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      <alt>Object &lt;b&gt;Bak&lt;/b&gt;:&lt;br/&gt;Bcl-2 homologous antagonist/killer &lt;i&gt;Protein (Homo sapiens)&lt;/i&gt;&lt;br/&gt;Bcl-2 homologous antagonist/killer &lt;i&gt;Protein (Mus musculus)&lt;/i&gt;&lt;br/&gt;BCL2-antagonist/killer 1 &lt;i&gt;Protein (Rattus norvegicus)&lt;/i&gt;</alt>
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